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Literature summary extracted from

  • Nakamura, A.; Arai, H.; Fujita, N.
    Centrosomal Aki1 and cohesin function in separase-regulated centriole disengagement (2009), J. Cell Biol., 187, 607-614.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.49 Scc1 + H2O Homo sapiens Scc1 is a subunit of cohesion, centrosomal Scc1 is cleaved by separase coincidentally with chromatin Scc1 fragments of Scc1
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Organism

EC Number Organism UniProt Comment Textmining
3.4.22.49 Homo sapiens
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.49 HEK-293T cell
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 Homo sapiens
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3.4.22.49 HeLa cell
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 Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.49 Scc1 + H2O Scc1 is a subunit of cohesion, centrosomal Scc1 is cleaved by separase coincidentally with chromatin Scc1 Homo sapiens fragments of Scc1
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 ?

General Information

EC Number General Information Comment Organism
3.4.22.49 physiological function sister chromatid separation at anaphase is triggered by cleavage of the cohesin subunit Scc1, which is mediated by separase Homo sapiens